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**What is the difference between HPMC K4M and K100M?**.
HPMC, commonly known as hydroxypropyl methylcellulose, is a type of cellulose ether widely used in the pharmaceutical, food, and cosmetic industries for its thickening, stabilizing, and film-forming properties. The main difference between HPMC K4M and K100M lies in their molecular weights.
HPMC K4M has a lower molecular weight compared to HPMC K100M. The number "4" and "100" in their names indicate their respective viscosity grades, with K4M having a viscosity of around 4000 mPa·s and K100M having a viscosity of around 100,000 mPa·s. As a result, HPMC K100M typically has better thickening and film-forming properties than HPMC K4M.
In practical applications, the choice between HPMC K4M and K100M depends on the specific requirements of the formulation. For example, HPMC K4M may be preferred for applications where a lower viscosity and faster dissolution rate are desired, such as in immediate-release tablets. On the other hand, HPMC K100M may be more suitable for sustained-release formulations that require a higher viscosity for controlled drug release.
In summary, the key difference between HPMC K4M and K100M is their molecular weight and viscosity, which influences their performance in terms of thickening, film-forming, and other properties in various applications within the pharmaceutical, food, and cosmetic industries.
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